In theory, yes.
But it would take some modding to the index.php file, and probably the admin.php file as well.
Not an easy task.
You would probably need to make a new row in the database for the url "name" and have the admin.php file put some info in it. And you would need to change the way index.php does links... it works off and ID row, you would need to change it to your url "name" row instead.
This is now possible. I created an addon for Pixelpost that will do this.
Go to http://forum.pixelpost.org/showthread.php?t=4915 for more information.